产品名称
南宫28抗人HLA-A,B,C抗体(W6/32)(货号:FHM00110)是一款针对人类主要组织相容性复合体(MHC)I类抗原的高特异性单克隆抗体。该抗体可有效识别HLA-A、B及C位点的非多态性表位,在细胞介导的免疫反应和肿瘤监测中发挥重要作用。

产品特点
W6/32单克隆抗体与β2-微球蛋白相关,并在所有人类有核细胞中广泛表达。该抗体能同时识别43 kDa和11-12 kDa的抗原链,具有良好的交叉反应性,适用于狒狒、恒河猴及食蟹猴等多个物种。
产品信息
南宫28抗人HLA-A,B,C抗体(W6/32)的详细参数如下:
- 货号:FHM00110
- 种属反应性:人类
- 宿主:小鼠
- 同种型:IgG2a,kappa
- 克隆类型:单克隆
- 偶联物:未偶联
- 浓度:6 mg/ml
- 纯度:95%(通过SDS-PAGE验证)
- 纯化方式:通过Protein A/G从细胞培养上清液中纯化
- 克隆号:W6/32
- 适用领域:ELISA、流式细胞术(FCM)、细胞免疫组化(ICC)、组织切片免疫组化(IHC-Fr)、免疫沉淀(IP)、西方印迹(WB)
- 状态:液体
- 保存条件:短期4°C(1-2周),长期-20°C(12个月),更长期-80°C保存
参考文献
- Mapping of the monoclonal antibody W6/32: sensitivity to the amino terminus of beta2-microglobulin PMID:9672158
- The Structural Basis for Recognition of Human Leukocyte Antigen Class I Molecules by the Pan-HLA Antibody W6/32 PMID:39093013
- Residue 3 of beta2-microglobulin affects binding of class I MHC molecules by the W6/32 antibody PMID:10079295
- Expression of the W6/32 HLA epitope by cells of rat, mouse, human and others species: critical dependence on the interaction of specific MHC heavy chains with human or bovine beta2-microglobulin PMID:2443365
- Biotinylation of class I MHC molecules abrogates recognition by W6/32 antibody PMID:10395109
- An novel strategy of c-myc oncogene in NK activity regulation not related to the W6/32 MHC class I epitope PMID:7516924
- Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C antigens PMID:87477
- Quantitative analysis of platelet surface HLA by W6/32 anti-HLA monoclonal antibody PMID:3742047
- Monomorphic anti-HLA monoclonal antibody (W6/32) recognizes polymorphic H-2 heavy chain determinants exposed by association with bovine or human but not murine beta2-microglobulin PMID:3316135
- Enhancement of tumor cell lysis by natural killer cells after blocking of HLA monomorphic determinant using F(ab')2 fragment of W6/32 PMID:9544438
有关产品的更多信息,请咨询南宫28的中国授权总代理——武汉佰乐博生物技术有限公司。作为法国南宫28品牌在亚洲区的授权总代理,我们提供近3万种核心生命科学试剂,包括蛋白质、抗体等,旨在为科研人员提供全面可靠的高品质产品和服务。
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